![]() ![]() PPIs are among the most commonly used classes of drugs in the U.S.įor the study, researchers sifted through de-identified medical records in a database maintained by the U.S. PPIs - sold under brand names such as Prevacid, Prilosec, Nexium and Protonix - bring relief by reducing gastric acid. Other researchers independently have linked PPIs to adverse health problems such as dementia, bone fractures, heart disease and pneumonia, among others. He has led several studies associating PPIs to chronic kidney disease and an increased risk of death. “Taking PPIs over many months or years is not safe, and now we have a clearer picture of the health conditions associated with long-term PPI use,” said senior author Ziyad Al-Aly, MD, an assistant professor of medicine at the School of Medicine. ![]() The study is published online May 30 in the journal The BMJ. The researchers also found that such risk increases with the duration of PPI use, even when the drugs are taken at low doses. Further, many millions more purchase the drugs over the counter and take them without being under a doctor’s care and often indefinitely. ![]() More than 15 million Americans have prescriptions for PPIs. Louis Health Care System has linked long-term use of such drugs - called proton pump inhibitors (PPIs) - to fatal cases of cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer. Now, a study by researchers at Washington University School of Medicine in St. However, little has been known about the specific causes of death attributed to the drugs. The researchers found that such risks increase with the duration of PPI use, even when taken at low doses.Įxtended use of popular drugs to treat heartburn, ulcers and acid reflux has been associated with an increased risk of premature death. Louis Health Care System has linked long-term use of drugs known as proton pump inhibitors (PPIs) to fatal cases of cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer. Washington UniversityĪ study from researchers at Washington University School of Medicine in St.News Release Heartburn drugs linked to fatal heart and kidney disease, stomach cancerĭeath risk increases the longer such drugs are usedīy Kristina Sauerwein ![]()
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